The EXSCALATE4CoV (E4C) project

E4C is a public-private consortium supported by the European Commission’s Horizon 2020 tender for projects to counter the Coronavirus pandemic and improve the management and care of patients.
At the core of E4C is Exscalate (EXaSCale smArt pLatform Against paThogEns), at present the most powerful and cost-efficient intelligent supercomputing platform in the world. Exscalate has a "chemical library" of 500 billion molecules and a processing capacity of more than 3 million molecules per second. The E4C consortium, coordinated by Dompé Farmaceutici , is composed by 18 institutions from seven European countries.

JOIN E4C CONSORTIUM TO HELP IDENTIFY NEW TREATMENTS AGAINST SARS-COV-2

The information you provide will be used as inpt into our High Performance Computing resources for virtual screening against prioritytarget protein structures.

THE MEMBERS OF CONSORTIUM ARE COMMITTED TO OPEN ACCESS PUBLISHING

As part of its dissemination plan, E4C consortium is making a repository available here for publications originating from the project's activities following green open access principles.

RESULTS

 

SIB Swiss Institute of Bioinformatics

Summary
Generation of homology models based on the mapped functional proteins of the entire sequenced SARS-CoV-2 viral genome

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PROTEIN PRODUCTION AND TARGET BASED ASSAYS

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PHENOTYPIC SCREEN

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ELETTRA SINCROTRONE TRIESTE

Summary
The structural biology team of Elettra Sincrotrone Trieste has achieved first results on SARS-CoV-2 Mpro viral protein by setting up a reproducible expression and purification protocol

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GENOMICS

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MECHANISM OF ACTION

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AUTOMATED HOMOLOGY MODELING WORKFLOW FOR DRUG TARGET

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POLIMI, CINECA

Summary
n the WP8 “Production and tuning on HPC infrastructure”, the POLIMI team is responsible for the continuous tuning and code adaptation of the EXSCALATE platform, and contributes to its porting on the new Marconi100 partition at CINECA.

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REGULATORY CONTRACTS

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CHELONIA

Summary
Setup and Maintenance of Website & Social Media (D10.1).

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Consortium

League

   

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Address

Exscalate4cov
c/o Dompé Farmaceutici
Via Pietro Castellino, 111
80131 Napoli, Italy